This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
References
Rett Syndrome in Humans
1. National Institute of Neurological Disorders and Stroke. (2008, June 6) Rett Syndrome Fact Sheet. Retrieved February 2, 2009, from http://www.ninds.nih.gov/disorders/rett/detail_rett.htm.
2. Families.com. (2006, June 10) Rett Syndrome: A Brief Overview. Retrieved February 27, 2009, from http://special-needs.families.com/blog/rett-syndrome-a-brief-overview.
3. Society for Neuroscience (2009) Brain Briefings - Rett Syndrome. Retrieved February 12, 2009 from http://www.sfn.org/skins/main/images/brainbriefings/bb_April2007_large.jpg.
4. Entrez Gene. (2009, January 12) MECP2 methyl CpG 2 binding protein (Rett Syndrome). Retrieved February 2, 2009 from http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005.
5. Monteggia, L.M., Kavalali, E.T. (2009) Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission. Biological Psychiatry 65 (3) 204-10
6. U.S. National Library of Medicine (2009, January 30) Genetics Home Reference: MECP2. Retrieved February 2, 2009, from http://ghr.nlm.nih.gov/gene=mecp2.
Literature
1. Wade, N. (2007) “Progress is Reported on a Type of Autism” The New York Times.
2. Guy, J., Gan, J., Selfridge, J., Cobb, S., Bird, A. (2007) Reversal of Neurological Defects in a Mouse Model of Rett Syndrome. Science. 315 (23) pg. 1143-1147.
Gene
1. Gene Cards - http://www.genecards.org/
2. Homologene - http://www.ncbi.nlm.nih.gov/homologene
3. BLAST (nucleotide) - http://blast.ncbi.nlm.nih.gov/Blast.cgi
4. MOTIF - http://motif.genome.jp/
5. MEME - http://meme.sdsc.edu/meme4/intro.html
Microarray
1. GEO - http://www.ncbi.nlm.nih.gov/geo/
2. Deng V, Matagne V, Banine F, Frerking M et al. FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet 2007 Mar 15;16(6):640-50. PMID: 17309881.
3. Princeton GO Term Finder: http://go.princeton.edu/cgi-bin/GOTermFinder
Protein
1. Homologene - http://www.ncbi.nlm.nih.gov/homologene
2. BLAST (protein) - http://blast.ncbi.nlm.nih.gov/Blast.cgi
3. TCOFFEE - http://www.phylogeny.fr/version2_cgi/one_task.cgi?task_type=tcoffee
4. ClustalW - http://www.phylogeny.fr/version2_cgi/one_task.cgi?task_type=clustalw
5. Tree Top - http://www.genebee.msu.su/services/phtree_reduced.html
6. Phylogeny.fr - http://www.phylogeny.fr/
7. Pfam - http://pfam.sanger.ac.uk/
8. SMART - http://smart.embl-heidelberg.de/
9. Nan X, Meehan RR, Bird A; , Nucleic Acids Res 1993;21:4886-4892.: Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. PUBMED:8177735
10. Sasahara K, Yamaoka T, Moritani M, Tanaka M, Iwahana H, Yoshimoto K, Miyagawa J, Kuroda Y, Itakura M; , Biochem Biophys Res Commun. 2000;269:444-450.: Molecular cloning and expression analysis of a putative nuclear protein, SR-25. PUBMED:10708573
11. Uniprot - http://www.uniprot.org/
12. Protein Data Bank - http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=1QK9
13. ExPASy - http://us.expasy.org/tools/#primary
Interactions
1. String - http://www.weebly.com/weebly/main.php#
Gene Ontology
1. AmiGO
Phenotypes
1. Fyffe, S. et al. (2008) Deletion of Mecp2 in SIM-1 expressing neurons reveals a critical role for Mecp2 in feeding behavior, aggression, and the response to stress. Neuron 59, 947-958.
2. Bissonette, J., Knopp, S. (2006) Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Pediatric Respiration. 59 (4 Pt 1), 513-518.
Other Useful Links
RettBASE
MECP2 search engine and database.
International Rett Syndrome Foundation
Information about Rett Syndrome, current research, and resources for families
MAYO Clinic Rett Syndrome Page
Information about the disease, diagnosis, treatment, and support
WEMOVE Rett Syndrome Page
Education and awareness for movement disorders such as Rett Syndrome
MECP2.org.uk
Website designed to collate and display mutation and symptom information from Rett Syndrome patients to allow the analysis of how symptoms correlate with MeCP2 mutation status.
MECP2 Gene Detail
Developed by the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
Jessica Connor
[email protected]
Last Updated: 5/11/09